Cheung Glutamatergic Regimen and Hypotheses​

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• Cheung N (2026) DXM, CYP2D6-inhibiting antidepressants, piracetam, and glutamine: proposing a ketamine-class antidepressant regimen with existing drugs. Front. Psychiatry 17:1751605. doi: 10.3389/fpsyt.2026.1751605

• Cheung N. (2026). The Cheung Glutamatergic Regimen as a candidate for primary and secondary prevention of Alzheimer's disease onset. Journal of Alzheimer's disease reports, 10, 25424823261433953. https://doi.org/10.1177/25424823261433953

• Cheung N. (2026). A Developmental Taxonomy of Autism and the Precision Timing of the Cheung Glutamatergic Regimen. Cureus, 18(4), e107120. https://doi.org/10.7759/cureus.107120

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CGR Case Reports and Series

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CGR-Classic

• Cheung, N. (2026). Oral glutamatergic modulation with dextromethorphan and piracetam for refractory bipolar disorder with obsessive-compulsive disorder: Three consecutive cases from routine practice. Journal of Clinical Psychiatry, 87(2), Article 25cr16262. https://doi.org/10.4088/JCP.25cr16262

• Cheung N (2026) Case Report: Oral glutamatergic augmentation for trauma-related disorders with fluoxetine-/bupropion-potentiated dextromethorphan ± piracetam: a four-patient case series. Front. Psychiatry 17:1752101. doi: 10.3389/fpsyt.2026.1752101

• Cheung N (2026) Longitudinal Management of Post-traumatic Brain Injury Bipolar-Spectrum Disorder With Low-Dose Oral Glutamatergic Augmentation: Extended Follow-Up Revealing Induction, Overshoot, Stabilization, and Transition to PRN Maintenance. Cureus 18(5): e108595. doi:10.7759/cureus.108595

• Cheung N (2026) Longitudinal Outcomes of Oral Glutamatergic Augmentation in Trauma-Related Dissociation: A Six-Month Case Study. Cureus 18(5): e108751. doi:10.7759/cureus.108751

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CGR-Variants

• Cheung N (2026) Glutamatergic Enhancement Using As-Needed Dextromethorphan and Piracetam in a Stimulant-Partially Responsive Adult With ADHD: A Single-Case Report. Cureus 18(2): e104031. doi:10.7759/cureus.104031

• Cheung N (2026) Transient Mood Elevation Without a Manic Switch: Goldenseal-Augmented Oral Glutamatergic Regimen in Bipolar Depression With Comorbid Obsessive-Compulsive Disorder (OCD). Cureus 18(2): e104209. doi:10.7759/cureus.104209​

• Cheung N (2026) Marked Improvement in Treatment-Intolerant Obsessive-Compulsive Disorder in an Adolescent Using a Glutamatergic Regimen With Dextromethorphan, Piracetam, and Goldenseal Root. Cureus 18(3): e104617. doi:10.7759/cureus.104617

• Cheung N (2026) Inhibitor-Free Variant of the Cheung Regimen: Successful Adjunctive Therapy in Long-Standing Hypochondriasis With Prominent Somatic Features. Cureus 18(3): e105367. doi:10.7759/cureus.105367

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Et Alia

• Cheung HK, Cheung N (2026) Optimized Oral Glutamatergic Augmentation in Refractory Home-Dominant Contamination Obsessive-Compulsive Disorder With Somatic, Affective, and Motivational Features: A Case Report of Incremental Functional Gains. Cureus 18(6): e111573. doi:10.7759/cureus.111573

• Cheung HK, Cheung N (2026) Differential Improvement in Obsessive Rumination and Fantasy Intrusions Versus Attachment-Related Emotional Dysregulation During Oral Glutamatergic Augmentation in a 16-Year-Old Adolescent. Cureus 18(7): e112492. doi.org/10.7759/cureus.112492

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Genomics and Epigenomics

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Alzheimer's Disease

• Cheung, N. (2026). Brain transcriptome-wide association study reveals selective long-term potentiation enrichment and negative directional skew of senescence-regulation pathways in Alzheimer’s disease. Journal of Alzheimer’s Disease Reports, 10. https://doi.org/10.1177/25424823261468711

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ADHD

• Cheung, N. (2026). Transcriptomic signatures of early- versus late-diagnosed ADHD and implications for treatment heterogeneity. Discover Mental Health. https://doi.org/10.1007/s44192-026-00540-2

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ALS

• Cheung N (2026) Synaptic Plasticity Fragility Underlies a Microglial Pruning Continuum in Major Depressive Disorder and Amyotrophic Lateral Sclerosis. Cureus 18(4): e107259. doi:10.7759/cureus.107259

• Cheung N (2026) Symptom-Level Precision Neurology in Amyotrophic Lateral Sclerosis (ALS): Linking Microglial Pruning, Mitochondrial Nicotinamide Adenine Dinucleotide (NAD+) Compensation, and Autophagy Failure Across the Aging Spectrum. Cureus 18(5): e109147. doi:10.7759/cureus.109147​​

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OCRD

• Cheung, N. (2026). Autophagy-related gene-set signals in the genetic architecture of obsessive-compulsive disorder: A hypothesis-generating link to nicotinamide adenine dinucleotide-associated cellular maintenance biology. Cureus, 18(7), Article e113327. https://doi.org/10.7759/cureus.113327

• Cheung N (2026) Convergence in Pruning and Circadian Regulation in Obsessive-Compulsive Disorder and Allergic Diseases: Evidence From a Secondary Genome-Wide Analysis. Cureus 18(5): e109781. doi:10.7759/cureus.109781

• Cheung N (2026) Opposing Molecular Programs in Obsessive-Compulsive Disorder and Hoarding: Transcriptome-Wide Association Studies Reveal Distinct Senescence, Complement, and Metabolic Signatures. Cureus 18(6): e110702. doi.org/10.7759/cureus.110702

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PTSD

• Cheung N (2026) Posttraumatic Stress Disorder (PTSD) NAD/Sirtuin Deficiency and SARM1-Mediated Synaptic Vulnerability: Evidence for Accelerated Brain Aging Subtypes. Cureus 18(6): e110755. doi.org/10.7759/cureus.110755

• Cheung, N. (2026). Polycomb-derived posttraumatic stress disorder (PTSD) signals diverge from classical aging pathways and converge on neuroimmune genes. Cureus, 18(7), e112717. https://doi.org/10.7759/cureus.112717

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SUD​

• ​Cheung N (2026) Cross-Disorder Pruning-Plasticity-Aging Architecture in Substance Use Disorders and Anxiety: Transcriptome-Wide Association Insights and Mechanistic Synthesis. Cureus 18(6): e110806. doi.org/10.7759/cureus.110806

• Cheung N (2026) Opposing Ageing-Related Transcriptomic Profiles Distinguish Opioid Exposure Liability From Dependence Liability. Cureus 18(6): e111258. doi.org/10.7759/cureus.111258

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Pharmaco​genomics

• Cheung, N. (2026). Multi-ancestry transcriptome-wide association study (TWAS)-informed prioritization of antipsychotic metabolic risk: Evaluation of GLP1R as a shared mechanistic link. Cureus, 18(7), e112759. https://doi.org/10.7759/cureus.112759

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Epigenomics

• Cheung N (2026) Focal Polycomb-Mediated Repression of Neuronal Identity and Synaptic Maintenance Genes in Aging Neurons. Cureus 18(6): e111824. doi.org/10.7759/cureus.111824

• Cheung, N. (2026). DNA methylation at core N-methyl-D-aspartate (NMDA) receptor genes reveals a glutamatergic signature of aging in post-COVID whole blood with implications for long-COVID neuropsychiatric sequelae. Cureus, 18(7), e112902. https://doi.org/10.7759/cureus.112902

• CPT2 as a convergent node linking age-associated neuronal H3K27me3 remodeling to nicotinamide mononucleotide (NMN)-induced expression rescue in metabolic tissues. (2026). Cureus, 18(7), e112906. https://doi.org/10.7759/cureus.112906

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Computational Biology

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• Cheung, N. (2026). Phased pruning in neural networks recapitulates selectivity–fragility trade-offs in brain development. Scientific Reports. https://doi.org/10.1038/s41598-026-62244-5

• Cheung, N. (2026). Structural synaptogenesis superior to functional modulation in a pruning-based recurrent network model of OCD. Frontiers in Computational Neuroscience, 20, Article 1799705. https://doi.org/10.3389/fncom.2026.1799705

• Cheung N. (2026). Divergent Mechanisms of Antidepressant Efficacy: A Unified Computational Comparison of Synaptogenesis, Stabilization, and Tonic Inhibition in a Model of Depression. Cureus, 18(3), e105040. https://doi.org/10.7759/cureus.105040