Cheung Glutamatergic Regimen and Hypotheses​

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• Cheung N (2026) DXM, CYP2D6-inhibiting antidepressants, piracetam, and glutamine: proposing a ketamine-class antidepressant regimen with existing drugs. Front. Psychiatry 17:1751605. doi: 10.3389/fpsyt.2026.1751605

• Cheung N. (2026). The Cheung Glutamatergic Regimen as a candidate for primary and secondary prevention of Alzheimer's disease onset. Journal of Alzheimer's disease reports, 10, 25424823261433953. https://doi.org/10.1177/25424823261433953

• Cheung N. (2026). A Developmental Taxonomy of Autism and the Precision Timing of the Cheung Glutamatergic Regimen. Cureus, 18(4), e107120. https://doi.org/10.7759/cureus.107120

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CGR Case Reports and Series

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• Cheung, N. (2026). Oral glutamatergic modulation with dextromethorphan and piracetam for refractory bipolar disorder with obsessive-compulsive disorder: Three consecutive cases from routine practice. Journal of Clinical Psychiatry, 87(2), Article 25cr16262. https://doi.org/10.4088/JCP.25cr16262

• Cheung N (2026) Case Report: Oral glutamatergic augmentation for trauma-related disorders with fluoxetine-/bupropion-potentiated dextromethorphan ± piracetam: a four-patient case series. Front. Psychiatry 17:1752101. doi: 10.3389/fpsyt.2026.1752101

• Cheung N (2026) Glutamatergic Enhancement Using As-Needed Dextromethorphan and Piracetam in a Stimulant-Partially Responsive Adult With ADHD: A Single-Case Report. Cureus 18(2): e104031. doi:10.7759/cureus.104031

• Cheung N (2026) Transient Mood Elevation Without a Manic Switch: Goldenseal-Augmented Oral Glutamatergic Regimen in Bipolar Depression With Comorbid Obsessive-Compulsive Disorder (OCD). Cureus 18(2): e104209. doi:10.7759/cureus.104209​

• Cheung N (2026) Marked Improvement in Treatment-Intolerant Obsessive-Compulsive Disorder in an Adolescent Using a Glutamatergic Regimen With Dextromethorphan, Piracetam, and Goldenseal Root. Cureus 18(3): e104617. doi:10.7759/cureus.104617

• Cheung N (2026) Inhibitor-Free Variant of the Cheung Regimen: Successful Adjunctive Therapy in Long-Standing Hypochondriasis With Prominent Somatic Features. Cureus 18(3): e105367. doi:10.7759/cureus.105367

• Cheung N (2026) Longitudinal Management of Post-traumatic Brain Injury Bipolar-Spectrum Disorder With Low-Dose Oral Glutamatergic Augmentation: Extended Follow-Up Revealing Induction, Overshoot, Stabilization, and Transition to PRN Maintenance. Cureus 18(5): e108595. doi:10.7759/cureus.108595

• Cheung N (2026) Longitudinal Outcomes of Oral Glutamatergic Augmentation in Trauma-Related Dissociation: A Six-Month Case Study. Cureus 18(5): e108751. doi:10.7759/cureus.108751
   

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Genomics

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• Cheung N (2026) Synaptic Plasticity Fragility Underlies a Microglial Pruning Continuum in Major Depressive Disorder and Amyotrophic Lateral Sclerosis. Cureus 18(4): e107259. doi:10.7759/cureus.107259

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Computational Psychiatry

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• Cheung N. (2026). Divergent Mechanisms of Antidepressant Efficacy: A Unified Computational Comparison of Synaptogenesis, Stabilization, and Tonic Inhibition in a Model of Depression. Cureus, 18(3), e105040. https://doi.org/10.7759/cureus.105040